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About
Darvon
Darvon's active ingredients are propoxyphene, a narcotic (opiate) pain
medication (analgesic), and acetaminophen (a non-narcotic pain medication),
which relieves pain better than either medication taken alone. propoxyphene
acts on the central nervous system and smooth muscle tissue, slowing the
central nervous system. It is not clear exactly how acetaminophen works to
ease pain.
Darvon is available with no
prescription.
Darvon has few side effects when
taken as recommended by your doctor, but some cautions should be observed.
Interactions may occur with certain medications that could alter or increase
the effect of either Darvon, or the other medication. While Darvon is a
highly effective pain reliever, it has been associated with an increased
risk of addiction when used improperly, or for too long. Never take Darvon
in greater doses, or for a longer period of time, than recommended by your
doctor.
Darvon Side Effects
Darvon side effects are usually mild, and tend to diminish over time. As
with all narcotic pain medications, it can impair performance. Driving or
operating heavy machinery is not advised, as Darvon can interfere with
mental and physical abilities. Become familiar with your reaction to Darvon
before performing potentially hazardous tasks while taking it.
Common Darvon side effects: are constipation, dizziness, dry mouth,
headache, itching, nausea, sedation, sweating, vomiting, or weakness. If you
feel lightheaded or nauseous, lying down may alleviate these symptoms.
Breathing: High doses of Darvon, or patient sensitivity, can cause
breathing irregularity or other respiratory depression. Respiratory
depression is the most serious likely side effect of Darvon, and may be more
likely with certain combinations of medication. Check the drug interaction
list carefully, and be cautious with any drug that slows the central nervous
system or 'may cause drowsiness.' If you have breathing difficulties, Darvon
may not be right for you.
Head Injuries: Propoxyphene's narcotic effects can cause an increase
of pressure in the cerebral and spinal fluid. If a patient has suffered a
head injury, both the pressure increase and the respiratory suppression can
be exaggerated. propoxyphene may interfere with an accurate diagnosis or
treatment of head injuries.
Acute Abdominal Conditions: Darvon may interfere with diagnosis and
treatment of acute abdominal conditions.
Dependence: Mental and physical dependence can develop if Darvon is
used for long periods of time. Long use of propoxyphene can create a
tolerance condition where the medication no longer works at the initial
dosage. Acetaminophen is not known to cause dependence.
Overdose: Propoxyphene overdose is characterized by slowed breathing,
extreme drowsiness progressing to stupor or coma, limp muscles, or cold,
clammy skin. Severe propoxyphene overdose may result in death due to cardiac
arrest or stopped breathing. Acetaminophen overdose can result in severe
liver poisoning, but rarely has this effect in doses under 10g. An overdose
of acetaminophen may not show symptoms for two to four days, but must be
treated within twenty-for hours to prevent liver damage or death. Seek
emergency medical treatment immediately if you suspect an overdose.
Darvon dosage for adults is usually started at 1-2 tablets every 4 hours at
a dosage of 50-100mg, and may be increased gradually if patient develops a
tolerance or is in extreme pain. If you have a kidney or liver condition, or
are a senior, your doctor may prescribe less frequent dosing. Severe side
effects rarely occur at the prescribed dosage of Darvon.
Many cases of drug overdose involving prescription medications are related
to mixing drugs that accelerate each other's effects. Never mix a powerful
medication like Darvon with another prescription drug that you or your
physician suspect may not be safe. Never mix Darvon with over the counter
medications that have not been approved by your doctor or pharmacist, and
avoid mixing it with street drugs of any type. Ignoring drug interaction
warnings has resulted in fatal overdose in some patients.
Cautions: Darvon should be prescribed with caution to patients with
Addison's disease or kidney, liver, thyroid, or urogenital tract problems.
Tell your doctor if you have ever had an allergic reaction to Darvon, or any
other medication.
Darvon Interactions
Darvon works by slowing the central nervous system. It should be used with
caution with other drugs that have similar effects. Darvon can change or
increase the effects of certain drugs, and your physician should be advised
if you are taking any of the following.
- Alcohol - Propoxyphene and alcohol can accelerate central nervous
system depression. Avoid mixing the two, as this could result in a fatal
overdose. Alcohol use combined with acetaminophen can accelerate or
increase the risk of liver damage or stomach bleeding.
- Anticonvulsant/Antiseizure medication may interact with your
treatment. Be especially cautious if you use Tegretol (carbamazepine), as
serious neurological disorders may result. Only your doctor can advise if
this combination is safe.
- Antihistamines like Tavist or Benadryl
- Aspirin (or any salicylate, such as salicylamide, or salicylic acid)
can cause kidney or liver damage when taken in high doses, and over long
periods of time, in combination with acetaminophen. When taken in the
recommended doses, for a short time, it has not been seen to produce this
effect.
- Benzodiazepines (a class of antidepressants, anti-panic agents, and
muscle relaxants) such as Ativan (lorazepam), Valium (diazepam), Halcion (triazolam),
Restoril (temazepam), Librium(chlordiazepoxide), Xanax (alprazolam),
Tranxene-SD (clorazepate), Paxipam (halazepam), ProSom (estazolam),
Klonopin (clonazepam), and others, should be used cautiously with Darvon.
- Coumadin (warfarin) - Increased risk of bleeding.
- Desyrel (trazodone) - Risk of additive CNS depression.
- MAO inhibitors - Propoxyphene must not be mixed with MAO (monoamine
oxidase) inhibitors such as the antidepressants Nardil, Marplan, or
Parnate. It should not be used within 2 weeks of stopping these
medications.
- Narcotic pain medication of any other kind, like Codeine, Demerol (meperidine),
Buprenex (buprenorphine), Darvon (propoxyphene hcl), Dilaudid (hydromorphone),
MS Contin or Kadian (morphine), nalbuphine, OxyContin (propoxyphene),
Stadol (butorphanol), Talwin compound (pentazocine), Vicodin (hydrocodone,
acetaminophen), or Vicoprofen (hydrocodone, ibuprofen) should not be mixed
with Darvon.
- Norflex (orphenadrine) - Risk of oversedation.
- Oral contraceptives - These may interact with acetaminophen
- Sedatives like Fioricet (butalbital, acetaminophen, and caffeine),
Fiorinal, Phenobarbitol, Seconal, or other barbiturates.
- Sleep medication like Ambien (zolpidem), Sonata (zaleplon), or over
the counter sleeping pills should be used with propoxyphene only as, and
if, advised by your doctor.
- Skeletal muscle relaxants - such as Flexeril (cyclobenzaprine),
Skelaxin (metaxalone), Soma (carisoprodol), or Robaxin (methocarbamol) may
increase respiratory depression when mixed with propoxyphene.
- Street drugs of any type must never be mixed with Darvon as this could
result in a fatal overdose.
- Tranquilizers such as Haldol (haloperidol), Mellaril (thioridazine),
or Thorazine (chlorpromazine) may cause oversedation.
- Trexan (naltrexone) - Causes narcotic pain medication to be
ineffective.
- Tricyclic antidepressants such as Elavil (amitriptyline), Asendin (amoxapine),
Anafranil (clomipramine), Pertofrane or Norpramin (desipramine), Sinequan
(doxepin), Tofranil (imipramine), Aventyl or Pamelor (nortriptyline),
Vivactil (protriptyline), and Surmontil (trimipramine), may increase the
central nervous system suppressant effects from either the antidepressant,
or the propoxyphene.
- Ultram (tramadol)
- Zidovudine (AZT, Retrovir) - Narcotic pain medication increases blood
levels of this drug, potentially making side effects more severe.
- In addition to the above medications, tell your doctor if you are
using any other major antidepressants or central nervous system
depressants in combination with Darvon. Be cautious about taking Darvon
with any medicine warning that it 'may cause drowsiness.'
Do not mix this propoxyphene-acetaminophen combination with over the
counter pain medication; acetaminophen can cause liver damage when mixed
with certain pain medications. Check any cold or flu medication you may need
to take to be sure it does not contain additional pain medication.
Darvon Dosages
Darvon dosage for adults is usually started at one one or two tablets every
four hours, as needed. The tablets are capsule shaped, dark orange, with
"Darvon-N" printed in black. Either "50" or "100" will be printed below,
depending on the capsule's dosage of propoxyphene napsylate.
Darvon is manufactured in the following dosages (propoxyphene /
acetaminophen):
Darvon Directions
If you miss a dose of Darvon, take it as soon as you remember. If you are
more than halfway through your dose interval, skip the missed dose and go
back to your schedule. Taking double doses of Darvon is not recommended, as
it may lead to an overdose or dependence.
Do not crush tablets before taking, as this could release the drug into the
bloodstream too fast, possibly resulting in an overdose.
Darvon and Pregnancy
Darvon has not been well studied for effects during pregnancy. Caution is
advised in prescribing Darvon to pregnant women.
Babies born to mothers taking opiates like propoxyphene can experience
withdrawal symptoms after birth. The propoxyphene withdrawal symptoms in the
baby may include: irritability, hyperactivity, tremors, faster breathing,
increased stools, fever, vomiting, sneezing, and yawning. The severity of
the symptoms is not always tied to how much, or how long the mother used
propoxyphene (or other opiate).
Darvon and Children
Darvon has not been well studied for effects on children.
Darvon and Seniors
Darvon does not seem to affect
the senior population differently, but your doctor may recommend dosages
that are farther apart.
There is a higher occurrence among the elderly of Addison's disease or
kidney, liver, thyroid, or urogenital tract problems.
Darvon should be prescribed with
care to these patients, and the elderly may have to be watched more
carefully for respiratory depression.
Darvon should be used cautiously
with any patient in a weakened condition.
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